| Name | District | Reason |
| Senator Joseph Boncore | First Suffolk and Middlesex | Moved to Massachusetts Biotechnology Council |
| Senator Sonia Chang-Diaz | Second Suffolk | Running for Governor |
| Representative Claire Cronin | 11th Plymouth | Confirmed as Ambassador to Ireland |
| Senator Diana DiZoglio | First Essex | Running for State Auditor |
| Representative Nikka Elugardo | 15th Suffolk | Running for Sentate Seat |
| Representative Tami Gouveia | 14th Middlesex | Running for Lt Governor |
| Representative Brad Hill | 4th Essex | Moved to Massachusetts Gaming Commission |
| Senator Adam Hinds | Pittsfield | Running for Lt. Governor |
| Representative Elizabeth Malia | 11th Suffolk | Retiring |
| Representative Paul Mark | 2nd Berkshire | Running for Senate Seat |
| Representative Maria Robinson | 6th Middlesex | Resigned |
| Representative Timothy Whelan | 1st Barnstable | Running for Barnstable County Sheriff |
| Governor Charlie Baker | | Not Running for Reelection |
| Lt. Governor Karen Polito | | Not Running for Reelection |
| Senator Eric Lesser | 1st Hampden & Hamphire | Running for Lt. Governor |
| District Attorney Johnathan Blodgett | Essex County | Not Running for Reelection |
| District Attorney Michael O’Keefe | Cape & Islands | Not Running for Reelection |
| Auditor Suzanne Bump | | Not running for Reelection |
| Representative Paul Tucker | 7th Essex | Running for Essex County District Attorney |
| Attorney General Maura Healey | | Running for Governor |
| Representative Linda Dean Campbell | 15th Essex | Not running for reelection |
| Representative Sheila Harrington | 1st Middlesex | Nominated for Clerk Magistrate, District Court |
| Representative Lori Ehrlich | 8th Essex | Moving to FEMA |
| Judge Paula Carey | | Retiring |
| District Attorney Rachel Rollins | | Confirmed as US Attorney |
| Barnstable County Sheriff James Cummings | | Retiring |
| Senator Harriette Chandler | Worcester | Retiring |
| Representative Carolyn Dykema | 8th Middlesex | Not running for reelection |
| Representative Jake Oliveira | 7th Hampden | Running for State Senate, 1st Hampden & Hampshire |
| Representative Joseph Wagner | 8th Hampden | Not running for reelection |
| Representative Shawn Dooley | 9th Norfolk | Running for State Senate, Norfolk, Bristol & Middlesex |
| Governor’s Councilor Mary Hurley | 8th District | Not running for reelection |
| Representative Thomas Golden | 16th Middlesex | Moved to City Manager, Lowell |
| Representative Christina Minicucci | 14th Essex | Not running for reelection |
